Introduction. The Dual-Action Debate: Does Pharmacology Matter?

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Major depressive disorder (MDD) is a common, often chronic, and not infrequently disabling condition. Remission has been established as the goal of short-term treatment of depression^1,2 and has become the standard by which treatment efficacy is evaluated. Moreover, achieving remission early in the course of illness can lead to improved long-term outcomes.^3,4 Pharmacotherapy, psychotherapy, and a combination of these approaches have been shown to be effective in the ambulatory management of MDD.’ ‹’ ‹