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For several years, the relative degree of response to treatment of depressive disorders has been the focus of intense discussion.1-3 For example, a consensus group convened nearly a decade ago to develop definitions for terms such as treatment response and remission, as well as relapse and recurrence of illness.4 The development of such concepts has allowed the field to focus on the important notion of achieving and maintaining full symptomatic (i.e., "syndromal") response in depression.