Introduction. Treatment-Resistant Schizophrenia and Beyond: Current Concepts and Future Prospects.

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The publication of the U.S. Clozaril Multicenter Trial more than a decade ago led to the worldwide use of clozapine (Clozaril, Leponex) for treatment-resistant schizophrenia.¹ Despite the subsequent introduction of other atypical antipsychotics, clozapine remains the "gold standard" for treatment of this patient population, with superior efficacy compared with conventional antipsychotics. Indeed, it is the only drug with proven efficacy in treatmentresistant schizophrenia.’ ‹