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This special symposium brings together 7 experienced researchers who have devotedtheir careers to improving the recognition and treatment of mental illness in both primary care and mental health systems. Methods to improve recognition of anxiety, depression,somatization, and suicidal behavior will be described as well as the development ofevidence-based treatment guidelines and exciting, pharmacologic treatment advances.Dr. Hirschfeld’s article helps frame the other presentations in this supplement in an historicalcontext.