Is Clozapine Safe in Patients With Preexisting Epilepsy? A Report of 2 Cases

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Sir: Clozapine is associated with seizures in 2% to 3% ofpatients who receive it.^1,2 This risk increases when patients havepreexisting neurologic abnormalities.² Langosch and Trimblehave described the use of clozapine in the treatment of psychosisin patients with epilepsy.³‘ ‹