Is the Problem of a High Placebo Response Unique to Antidepressant Trials?

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Recent studies questioning the effectiveness of antidepressantshave received considerable attention in the mass media.These articles report the difficulty in demonstrating superiorityof antidepressants over placebo among antidepressant trials.Interestingly, placebo response also plays a significant role intrials of other nonpharmacologic somatic treatments for depressionas well as treatments for many other chronic psychiatricand nonpsychiatric illnesses; however, this does not seem tohave received similar attention.’ ‹