Is Statin Use Safe in Individuals With Psychotic Disorders?

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Sir: Individuals with schizophrenia and other serious mentalillnesses have a mortality rate at least 2 times as high as thosewithout psychotic disorders, with the excess mortality largelyattributed to higher rates of death from cardiovascular disease.

Wider use of cholesterol-lowering drugs (statins) to reducecardiovascular risk in this setting has been suggested. However,widespread use of statin drugs in individuals with psychoticdisorders may raise some concerns.

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