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Last year, we inaugurated a series of occasional research and scholarly review articles with the intent of capturing some of the progress now being made in the scientific understanding, diagnosis, treatment, and prevention of Alzheimer’s disease (AD). In this issue of The Journal of Clinical Psychiatry, Andreas Papassotiropoulos, Michael Fountoulakis, Travis Dunckley, Dietrich Stephan, and I consider the progress now being made in the genetic, transcriptomic, and proteomic study of AD.

Twin studies suggest that about 75% of the risk for late-onset AD may be attributable to heritable risk factors.