This CME activity is expired. For more CME activities, visit CMEInstitute.com.
Find more articles on this and other psychiatry and CNS topics:
The Journal of Clinical Psychiatry
The Primary Care Companion for CNS Disorders
Article Abstract
Bipolar disorder is a highly episodic illness, and many patients require long-term or lifelong treatment to maintain a stable mood. Because depression is the dominant pole of both bipolar I and bipolar II disorder, maintenance therapy must prevent depressive recurrence. Although numerous treatment options exist for bipolar disorder, few have data supporting both short-term and long-term efficacy for bipolar depression. When choosing among treatments, clinicians must consider the existing evidence for the long-term effectiveness of various pharmacologic and psychosocial interventions for controlling all types of mood events.
From the Editors
Vol 87 • 2026 • Number 1
Read the Current Issue
ASCP Corner
Rethinking Amisulpride: Could N-Methylation Result in a New and Even Better Antipsychotic?
Original Research
How Many Criteria Should be Required to Define the DSM-5 Mixed Features Specifier in Depressed Patients?
Meta-Analysis
Effectiveness of Peer-Administered Interventions for Perinatal Depression or Anxiety
Original Research
Innovation in Psychiatric Drug Development: A Quantitative Analysis of FDA-Approved Psychiatric Drugs, 2012–2024
Brief Report
Exercise Reduces Dysphoria in Clinical High-Risk for Psychosis: A Randomized Controlled Trial
Clinical and Practical Psychopharmacology
Pregabalin in Pregnancy: Major Congenital Malformations, Other Birth Outcomes, and Neurodevelopmental Outcomes
Consensus Report on XT Use in Practice
Read the full report