Low-Dose d-Cycloserine for Depression?

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

To the Editor: Ketamine’s ability to bring about rapid and dramatic improvement in patients with refractory depression has biotech companies and clinicians scrambling for ketamine alternatives. d-cycloserine (DCS) showed efficacy in depression as early as 1959 but lay dormant until recently.

As published in the June 2015 issue of the Journal, Kantrowitz and colleagues used ketamine priming followed by a high dose of DCS (1,000 mg/d) with impressive results (also refer to the study by Heresco-Levy et al).