Low-Dose Risperidone and Quetiapine as Monotherapy for Comorbid Anxiety and Depression

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Sir: Up to 80% of patients with generalized anxiety disorder(GAD) suffer from a comorbid mood disorder.¹ Atypical antipsychoticsare frequently prescribed as off-label adjunctivetreatment for GAD and major depressive disorder (MDD); however,no studies have demonstrated the effectiveness of thesedrugs as monotherapy.^2,3 Here, we present a case series describingthe use of risperidone and quetiapine as monotherapy forGAD and MDD.’ ‹’ ‹