Mandibular Dystonia Associated With the Combination of Sertraline and Metoclopramide

Letter to the Editor

Sir: We report a case of mandibular dystonia that developed
after sertraline, a serotonin reuptake inhibitor (SRI), was added
to a chronic regimen of metoclopramide.

Case report. Ms. A, a 23-year-old white woman with no
prior history of depression, presented to our inpatient crisis unit
with a major depressive episode of 2 months’ duration. Her only
significant physical illness was gastroesophageal reflux, which
had been well controlled for the prior 6 months with metoclopramide
15 mg q.i.d.