Metabolic Side Effects of Second-Generation Antipsychotics in Children and Adolescents: A Different Story?

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In many clinical settings, secondgenerationantipsychotics are preferred overfirst-generation antipsychotics because theycause fewer acute¹ and chronic² neuromotorside effects. In addition, second-generationantipsychotics may have improved^3,4 andbroader⁵ efficacy and are potentially associatedwith somewhat lower rates of nonadherence⁶compared with those of the olderagents. However, since the late 1990s, the increasedrisk for weight gain associated withsecond-generation antipsychotics has becomea focus of attention.’ ‹’ ‹