Methodological Issues in a Comparative Study of Ziprasidone and Risperidone

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Sir: Regarding a trial recently reported in the Journal¹ comparing risperidone and ziprasidone in the short-term treatment of schizophrenia, we concur with the authors that "more head-to-head comparisons of antipsychotics are needed to discern the relative efficacy and safety profiles of these compounds."^(p1624) This trial furthers progress toward good comparative research in part by illustrating some methodological limitations applicable to future research. The article contains some broad conclusions that do not appear to be supported by the reported data.’ ‹