Nefazodone for Mood Disorder Associated With Epilepsy

Sir: Nefazodone, a newer antidepressant with a dual action on the serotonin system, is effective in major depression, comorbid anxiety and depression, and possibly other conditions such as panic disorder. It is a relatively safe drug with a favorable side effect profile, and its favorable effect on sleep has been documented. The present case is the first reported that demonstrates another possible indication of nefazodone: mood disorder associated with a general medical condition, in this case, seizure.