The Journal of
Clinical Psychiatry

Psychopharmacology

Brainstorms March 15, 1998

Nitric Oxide Physiology and Pharmacology

Stephen M. Stahl

J Clin Psychiatry 1998;59(3):101-102

Article Abstract

Issue: Nitric oxide gas (NO) is an unconventional neurotransmitter that is synthesized upon demand. In the brain, it may allow postsynaptic elements to talk back to presynaptic neurons. In peripheral tissues it mediates smooth muscle relaxation. Various pharmacologic agents can enhance or reduce the actions of NO.

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