Olanzapine and Blepharoclonus

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Sir: Olanzapine is an atypical neuroleptic associated with low risk of extrapyramidal symptoms (EPS).¹ However, recent case reports^2-4 suggest that some patients developed abnormal movements while taking olanzapine. Incidence of motor eyelid complications associated with atypical antipsychotics is uncommon, and only a few case reports of blepharospasm or Meige’s syndrome have been reported with risperidone and olanzapine.⁴‘ ‹’ ‹