Olanzapine for Cocaine Craving and Relapse Prevention in 2 Patients

Letter to the Editor

Sir: A major focus of research in treatment for cocaine and stimulant dependence has been pharmacologic interventions to decrease craving and prevent relapse. Various medications have shown promise in uncontrolled clinical trials, but most fail to show consistent advantage over placebo in double-blind, placebo-controlled trials. Despite this, many practitioners continue to try various medications in an effort to find some means of decreasing cocaine use in dependent patients.