Olanzapine, New-Onset Diabetes Mellitus, and Risk for Insulin Overdose

Letter to the Editor

Sir: Olanzapine and clozapine are atypical antipsychotics with some similarities. Kamran et al. reported the first published case of new-onset diabetes mellitus associated with clozapine. Although causality is not established, a subsequent study of individuals with schizophrenia treated with clozapine for up to 5 years showed that 36.6% developed diabetes. We report a case that illustrates a similar dilemma with olanzapine.