Oxybutynin and Intranasal Desmopressin for Clozapine-Induced Urinary Incontinence

Letter to the Editor

Sir: In their report on the efficacy of ephedrine in the treatment
of clozapine-induced urinary incontinence, Fuller et al.
report that in their clinical experience with hospitalized psychiatric
patients oxybutynin was ineffective in the management of
this side effect. We have found both oxybutynin and intranasal
desmopressin to be effective in the treatment of outpatients with
clozapine-induced urinary incontinence.

As part of the Continuing Care Division, a community-based
program of services for the severely and persistently mentally
ill, the Clozapine Treatment Program provides case management
and medical services to 71 patients with treatmentresistant
psychosis managed with clozapine.