Parkinsonism and Akathisia With Quetiapine: Three Case Reports

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Sir: Quetiapine, a dibenzothiazepine derivative producedby altering the structure of the clozapine molecule, has beenshown to have low to moderate affinity for the D₁, D₂, 5-HT_1A,and 5-HT_2A receptors and moderate to high affinity for the a1-and a₂-adrenergic receptors. Due to this receptor profile, quetiapinehas been claimed to have a low incidence of extrapyramidalside effects. Large controlled trials have also shown thatquetiapine is associated with placebo-level extrapyramidal sideeffects and akathisia in schizophrenia and bipolar disorder.’ ‹’ ‹