Physiologic Sleep Disorders Among Treatment-Responsive Depressed Patients With Residual Cognitive and Physical Symptoms

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Sir: Fava and colleagues’ ¹ informative work on persisting cognitive and physical symptoms in patients with major depressive disorder following long-term use of antidepressants theorizes that complaints such as memory and concentration difficulties and daytime fatigue and sleepiness are caused by medication side effects or residual symptoms of depression or both. A major strength of that study is the focus on patients who partially or fully responded to antidepressant medication. We would expect these patients to report less impairment; however, 53% reported forgetfulness and 52% reported sleepiness among several residual symptoms.¹‘ ‹