A Possible Case of Venlafaxine-Induced Stevens-Johnson Syndrome

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Sir: We report a case of Stevens-Johnson syndrome (SJS) believed to be induced by venlafaxine in a woman with major depressive disorder who showed improvement in her rash when venlafaxine was discontinued. This report emphasizes that prescribers must aggressively follow up patients who have rashes while on treatment with any antidepressant, discontinuing the medication as soon as a serious skin reaction is suspected and watching closely for the emergence of potentially life-threatening dermatologic conditions.