Possible Impact of Dropout in a Study of High-Dose Olanzapine and Prolactin Levels

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Sir: Prolactin elevation as a consequence of antipsychotic drug therapy may result in decreased sexual desire, difficulties in sexual performance, and gynecomastia in men and in amenorrhea, infertility, breast engorgement, and lactation in women.¹ Karagianis and Baksh2 studied 24 patients to determine whether high-dose (20-40 mg/day) olanzapine was associated with prolactin elevation. They found that there was no correlation between dose of olanzapine and prolactin level, that the highest elevation of prolactin was 20 ng/mL, and that only 21% of patients had (mildly) elevated prolactin levels.