A Possible Pharmacokinetic Interaction Between Fluoxetine and Acetylsalicylic Acid

Letter to the Editor

Sir: In rare instances, fluoxetine has been shown to cause
skin rashes. During fluoxetine treatment, our patient experienced
hives that resolved after antidepressant discontinuation,
only to recur when the patient took acetylsalicylic acid (ASA,
aspirin) for pain relief.

Case report. A 44-year-old healthy, physically active, white
man developed major depressive disorder after a period of extreme
stress.