Predicting Pharmacotherapy Outcome From a Retrospective Chart Study?

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Sir: We read with interest the report by Shetti et al.¹ in the December 2005 issue of the Journal on predicting nonresponse in obsessive-compulsive disorder (OCD). Though articles on predicting response to pharmacotherapy for OCD should be encouraged, this article gives rise to important methodological questions.

First, the authors plead for a more accurate definition of nonresponse in OCD, but fail to define nonresponse adequately.