Brainstorms July 21, 2009

The Prefrontal Cortex Is Out of Tune in Attention-Deficit/Hyperactivity Disorder

Stephen M. Stahl, M.D., Ph.D.

J Clin Psychiatry 2009;70(7):950-951

Article Abstract

Pyramidal neurons, shaped like a triangular pyramid, are key regulators of neuronal networks in the prefrontal cortex. These cortical networks send messages that can be either accepted as signals or ignored as noise. When the prefrontal cortex is functioning properly, pyramidal neurons within these networks can tell the difference between signals and noise.

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