Quetiapine in Patients With Tourette's Disorder: An Open-Label, Flexible-Dose Study

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Sir: Tourette’s disorder (TD), or Gilles de la Tourette’s syndrome, is a neuropsychiatric disorder, usually starting in early childhood, characterized by multiple motor and vocal tics.

Although the etiology of TD remains largely unknown, it has been hypothesized that overactivity or hypersensitivity of the D₂ receptors in the striatum plays a role.¹ This hypothesis is consistent with the proved effectiveness of central D2-blocking agents like haloperidol and pimozide that decrease the intensity and frequency of tics in approximately 70% of the patients.’ ‹