Refractory Generalized Anxiety Disorder

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Generalized anxiety disorder (GAD) has a lifetime prevalence in the US population of about 5.7%.Typically, GAD begins in early adulthood and tends to have a chronic and persistent course. The disorderfrequently presents comorbidly with other conditions, and about 90% of patients with GADhave at least 1 comorbid lifetime psychiatric disorder. Patients with GAD tend to be high users ofmedical services; the disorder is associated with significant physical as well as psychological symptomatologyand impacts health, family relationships, and employment. Pharmacologic and psychosocialtreatments are available for GAD.’ ‹