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  1. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam UMC, Amsterdam, The Netherlands
  2. Current affiliation: Department of Rehabilitation Medicine, Basalt, The Hague, The Netherlands
  3. Corresponding author: Siham Icho, MD, Amsterdam UMC Loc VUMC, Alzheimer Center, De Boelelaan 1118, Amsterdam, 1081 HZ, Netherlands ([email protected]).
  4. Department of Old Age Psychiatry, GGZ InGeest, Amsterdam Neuroscience, Amsterdam, The Netherlands
  5. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam UMC, Amsterdam, The Netherlands
  6. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam UMC, Amsterdam, The Netherlands
  7. Current affiliation: Department of General Medicine, Amsterdam UMC, Amsterdam, The Netherlands
  8. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam UMC, Amsterdam, The Netherlands
  9. Current affiliation: Department of Psychiatry, St Antonius Hospital, Utrecht, The Netherlands
  10. Department of Old Age Psychiatry, GGZ InGeest, Amsterdam Neuroscience, Amsterdam, The Netherlands
  11. Current affiliation: Department of Psychiatry, Reinier van Arkel, ‘s-Hertogenbosch, The Netherlands
  12. Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam UMC, The Netherlands
  13. Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam UMC, Amsterdam, The Netherlands
  14. Department of Neurosurgery, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam UMC, Amsterdam, The Netherlands
  15. Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
  16. Department of Old Age Psychiatry, GGZ InGeest, Amsterdam Neuroscience, Amsterdam, The Netherlands
  17. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam UMC, Amsterdam, The Netherlands
  1. Ducharme S, Dols A, Laforce R, et al. Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders. Brain. 2020;143(6):1632–1650. PubMed CrossRef
  2. Rascovsky K, Hodges JR, Knopman D, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011;134(Pt 9):2456–2477. PubMed CrossRef
  3. Woolley JD, Khan BK, Murthy NK, et al. The diagnostic challenge of psychiatric symptoms in neurodegenerative disease: rates of and risk factors for prior psychiatric diagnosis in patients with early neurodegenerative disease. J Clin Psychiatry. 2011;72(2):126–133. PubMed CrossRef
  4. Mendez MF, Lauterbach EC, Sampson SM; ANPA Committee on Research. An evidence-based review of the psychopathology of frontotemporal dementia: a report of the ANPA Committee on Research. J Neuropsychiatry Clin Neurosci. 2008;20(2):130–149. PubMed CrossRef
  5. Harciarek M, Cosentino S. Language, executive function and social cognition in the diagnosis of frontotemporal dementia syndromes. Int Rev Psychiatry. 2013;25(2):178–196. PubMed CrossRef
  6. Piguet O, Hodges JR. Behavioural-variant frontotemporal dementia: an update. Dement Neuropsychol. 2013;7(1):10–18. PubMed CrossRef
  7. Baez S, Herrera E, Villarin L, et al. Contextual social cognition impairments in schizophrenia and bipolar disorder. PLoS One. 2013;8(3):e57664. PubMed CrossRef
  8. Weightman MJ, Air TM, Baune BT. A review of the role of social cognition in major depressive disorder. Front Psychiatry. 2014;5:179. PubMed CrossRef
  9. Devenney EM, Ahmed RM, Halliday G, et al. Psychiatric disorders in C9orf72 kindreds: study of 1,414 family members. Neurology. 2018;91(16):e1498–e1507. PubMed CrossRef
  10. Yu K, Cheung C, Leung M, et al. Are bipolar disorder and schizophrenia neuroanatomically distinct? an anatomical likelihood meta-analysis. Front Hum Neurosci. 2010;4:189. PubMed CrossRef
  11. van Erp TGM, Walton E, Hibar DP, et al; Karolinska Schizophrenia Project. Cortical brain abnormalities in 4,474 individuals with schizophrenia and 5,098 control subjects via the enhancing neuro imaging genetics through meta analysis (ENIGMA) consortium. Biol Psychiatry. 2018;84(9):644–654. PubMed CrossRef
  12. Hibar DP, Westlye LT, van Erp TG, et al; Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar Endophenotypes. Subcortical volumetric abnormalities in bipolar disorder. Mol Psychiatry. 2016;21(12):1710–1716. PubMed CrossRef
  13. van Rooij D, Anagnostou E, Arango C, et al. Cortical and subcortical brain morphometry differences between patients with autism spectrum disorder and healthy individuals across the lifespan: results from the ENIGMA ASD Working Group. Am J Psychiatry. 2018;175(4):359–369. PubMed CrossRef
  14. Luo C, Hu N, Xiao Y, et al. Comparison of gray matter atrophy in behavioral variant frontal temporal dementia and amyotrophic lateral sclerosis: a coordinate-based meta-analysis. Front Aging Neurosci. 2020;12:14. PubMed CrossRef
  15. Radonjić NV, Hess JL, Rovira P, et al. Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders. Mol Psychiatry. 2021;26(6):2101–2110. PubMed CrossRef
  16. Anttila V, Bulik-Sullivan B, Finucane HK, et al; Brainstorm Consortium. Analysis of shared heritability in common disorders of the brain. Science. 2018;360(6395):eaap8757. PubMed
  17. Seelaar H, Kamphorst W, Rosso SM, et al. Distinct genetic forms of frontotemporal dementia. Neurology. 2008;71(16):1220–1226. PubMed CrossRef
  18. Khan BK, Yokoyama JS, Takada LT, et al. Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion. J Neurol Neurosurg Psychiatry. 2012;83(4):358–364. PubMed CrossRef
  19. Ducharme S, Bajestan S, Dickerson BC, et al. Psychiatric presentations of C9orf72 mutation: what are the diagnostic implications for clinicians? J Neuropsychiatry Clin Neurosci. 2017;29(3):195–205. PubMed CrossRef
  20. Mendez MF. Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation. Neuropsychiatr Dis Treat. 2018;14:657–662. PubMed CrossRef
  21. Galimberti D, Dell’Osso B, Altamura AC, et al. Psychiatric symptoms in frontotemporal dementia: epidemiology, phenotypes, and differential diagnosis. Biol Psychiatry. 2015;78(10):684–692. PubMed CrossRef
  22. Zhang FF, Peng W, Sweeney JA, et al. Brain structure alterations in depression: psychoradiological evidence. CNS Neurosci Ther. 2018;24(11):994–1003. PubMed CrossRef
  23. Briggs R, Carey D, Claffey P, et al. The association between frontal lobe perfusion and depressive symptoms in later life. Br J Psychiatry. 2019;214(4):230–236. PubMed CrossRef
  24. Dols A, Rhebergen D, Beekman A, et al. Psychiatric and medical comorbidities: results from a bipolar elderly cohort study. Am J Geriatr Psychiatry. 2014;22(11):1066–1074. PubMed CrossRef
  25. van der Flier WM, Scheltens P. Amsterdam dementia cohort: performing research to optimize care. J Alzheimers Dis. 2018;62(3):1091–1111. PubMed CrossRef
  26. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):263–269. PubMed CrossRef
  27. American Psychiatric Association. Diagnostic Criteria of the DSM-IV-TR, Dutch Translation. Lisse, The Netherlands: Swets en Zeitlinger; 2001.
  28. Öijerstedt L, Chiang HH, Björkström J, et al. Confirmation of high frequency of C9orf72 mutations in patients with frontotemporal dementia from Sweden. Neurobiol Aging. 2019;84:241.e21–241.e25. PubMed CrossRef
  29. Van Mossevelde S, van der Zee J, Cruts M, et al. Relationship between C9orf72 repeat size and clinical phenotype. Curr Opin Genet Dev. 2017;44:117–124. PubMed CrossRef
  30. Galimberti D, Reif A, Dell’osso B, et al. C9ORF72 hexanucleotide repeat expansion is a rare cause of schizophrenia. Neurobiol Aging. 2014;35(5):1214.e7–1214.e10. PubMed CrossRef
  31. Galimberti D, Reif A, Dell’Osso B, et al. C9ORF72 hexanucleotide repeat expansion as a rare cause of bipolar disorder. Bipolar Disord. 2014;16(4):448–449. PubMed CrossRef
  32. Leverich GS, Nolen WA, Rush AJ, et al. The Stanley Foundation Bipolar Treatment Outcome Network, I: longitudinal methodology. J Affect Disord. 2001;67(1-3):33–44. PubMed CrossRef
  33. Hill WD, Davies G, Liewald DC, et al; CHARGE Cognitive Working Group. Age-dependent pleiotropy between general cognitive function and major psychiatric disorders. Biol Psychiatry. 2016;80(4):266–273. PubMed CrossRef
  34. Lavoie MA, Plana I, Bédard Lacroix J, et al. Social cognition in first-degree relatives of people with schizophrenia: a meta-analysis. Psychiatry Res. 2013;209(2):129–135. PubMed CrossRef
  35. Bo Q, Dong F, Li X, et al. Comparison of cognitive performance in bipolar disorder, major depressive disorder, unaffected first-degree relatives, and healthy controls. Psychiatry Clin Neurosci. 2019;73(2):70–76. PubMed CrossRef
  36. Kuring JK, Mathias JL, Ward L. Prevalence of depression, anxiety and PTSD in people with dementia: a systematic review and meta-analysis. Neuropsychol Rev. 2018;28(4):393–416. PubMed CrossRef
  37. Herbert J, Lucassen PJ. Depression as a risk factor for Alzheimer’s disease: genes, steroids, cytokines and neurogenesis—what do we need to know? Front Neuroendocrinol. 2016;41:153–171. PubMed CrossRef
  38. Broce I, Karch CM, Wen N, et al; International FTD-Genomics Consortium. Immune-related genetic enrichment in frontotemporal dementia: an analysis of genome-wide association studies. PLoS Med. 2018;15(1):e1002487. PubMed CrossRef
  39. Yokoyama JS, Bonham LW, Sturm VE, et al. The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia. Neuroimage Clin. 2015;9:283–290. PubMed CrossRef
  40. Harciarek M, Malaspina D, Sun T, et al. Schizophrenia and frontotemporal dementia: shared causation? Int Rev Psychiatry. 2013;25(2):168–177. PubMed CrossRef
  41. Cooper JJ, Ovsiew F. The relationship between schizophrenia and frontotemporal dementia. J Geriatr Psychiatry Neurol. 2013;26(3):131–137. PubMed CrossRef
  42. Kennedy DP, Adolphs R. The social brain in psychiatric and neurological disorders. Trends Cogn Sci. 2012;16(11):559–572. PubMed CrossRef
  43. Schoder D, Hannequin D, Martinaud O, et al. Morbid risk for schizophrenia in first-degree relatives of people with frontotemporal dementia. Br J Psychiatry. 2010;197(1):28–35. PubMed CrossRef
  44. Moreno-Küstner B, Martín C, Pastor L. Prevalence of psychotic disorders and its association with methodological issues: a systematic review and meta-analyses. PLoS One. 2018;13(4):e0195687. PubMed CrossRef
  45. Lyall K, Croen L, Daniels J, et al. The changing epidemiology of autism spectrum disorders. Annu Rev Public Health. 2017;38(1):81–102. PubMed CrossRef
  46. Sullivan PF, Daly MJ, O’Donovan M. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet. 2012;13(8):537–551. PubMed CrossRef
  47. Oberman LM, Pascual-Leone A. Hyperplasticity in autism spectrum disorder confers protection from Alzheimer’s disease. Med Hypotheses. 2014;83(3):337–342. PubMed CrossRef
  48. Smoller JW, Finn CT. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet C Semin Med Genet. 2003;123C(1):48–58. PubMed CrossRef
  49. Dols A, Krudop W, Möller C, et al. Late life bipolar disorder evolving into frontotemporal dementia mimic. Neuropsychiatr Dis Treat. 2016;12:2207–2212. PubMed CrossRef
  50. Mendez MF, Parand L, Akhlaghipour G. Bipolar disorder among patients diagnosed with frontotemporal dementia. J Neuropsychiatry Clin Neurosci. 2020;32(4):376–384. PubMed CrossRef
  51. Merikangas KR, Jin R, He JP, et al. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry. 2011;68(3):241–251. PubMed CrossRef
  52. Nascimento C, Nunes VP, Diehl Rodriguez R, et al. A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2019;93:269–283. PubMed CrossRef
  53. van Swieten JC, Heutink P. Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia. Lancet Neurol. 2008;7(10):965–974. PubMed CrossRef
  54. Pottier C, Ravenscroft TA, Sanchez-Contreras M, et al. Genetics of FTLD: overview and what else we can expect from genetic studies. J Neurochem. 2016;138(suppl 1):32–53. PubMed CrossRef
  55. Scarioni M, Gami-Patel P, Timar Y, et al; Netherlands Brain Bank. Frontotemporal dementia: correlations between psychiatric symptoms and pathology. Ann Neurol. 2020;87(6):950–961. PubMed CrossRef