Reply to "Anger in Depressive Mixed States"

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Sir: In his letter, Benazzi shares data from a large data set showing the predictive value of hypomanic symptoms for anger in major depressive episodes (MDEs). Here, we address 2 issues of research and clinical significance. In Table 2 of our article,¹ we presented data on the predictionof anger attacks in bipolar depression when hypomanic symptoms, depressive symptoms, and trait anger were simultaneously entered as independent variables into the regression equation.