Reply to Applying Parsimony to "An African Patient With Ziprasidone Intolerance"

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Sir: Our letter is the first report of a dramatically increasedserum concentration of ziprasidone and the second report of theoccurrence of severe side effects with that same medication,both effects occurring despite a demonstrably normal dose ofthe drug. As it happens, both patients in question had an Africanethnic background.The great William of Occam suggested that "entities are notto be multiplied beyond necessity,"¹ the principle that has becomeknown as "Occam’s razor."’ ‹