Reply to Comment on "Lithium and Clozapine Rechallenge: A Retrospective Case Analysis."

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: We are grateful to Dr. Esposito for his comments on distinguishing benign from malignant neutropenia. We agree that tests to distinguish the two may be of considerable benefit to clinical decision making where continuing with clozapine is a possibility. However, as our article1 describes, the rules in the United Kingdom are quite strict about clozapine prescription, so that persevering with clozapine despite the occurrence of a neutropenia is not normally possible.’ ‹