Reply to Indexing of Reports on Aripiprazole Augmentation of Clozapine

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Sir: We thank Dr. Ashton for his interest in our letter. It is encouraging to see that other psychiatrists have tried aripiprazole at higher doses and also in combination with other atypical antipsychotics in treatment-resistant schizophrenia.

While the issue of using high doses of antipsychotics and combining 2 atypicals is still debatable, we agree with Dr. Ashton that more reporting of such cases would enhance understanding of and also stimulate research in this area.’ ‹