Reply to Letter to the Editor "Clozapine-Related Speech Disturbance"

Letter to the Editor

Sir: We are pleased at Dr. Knoll’s interest in our report1 on clozapine-induced myoclonus. Similar to the course in four of our patients, clozapine-related myoclonus in the case described by Dr. Knoll was relieved after clozapine dose reduction. We have gathered more positive experience with the addition of carbamazepine in clozapine-induced myoclonus, a procedure we apply if a clozapine dose reduction is connected to a significant deterioration in psychotic symptoms in otherwise neuroleptic-resistant schizophrenics.