Reply to Letter to the Editor "Guideline Series Commentary"

Letter to the Editor

Sir: We appreciate the thoughtful comments received regarding the Expert Consensus Guidelines for bipolar disorder and schizophrenia. Dr. Weiss makes the important point that cognitive deficits are major determinants of disability in patients with schizophrenia and that we did not address this topic in the first iteration of our project. There are indications that when patients switch from typical to atypical antipsychotics, small improvements occur in certain cognitive domains.