Reply to "It looks like "Bradyphylaxis" to Me."

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Sir: I thank Dr. Jefferson for his interest in our work,¹ whichdescribed recurrences of major depression despite full doses ofmaintenance medication. We observed such recurrences in 25%of the cases in which study subjects were maintained on theirantidepressant therapy after successful treatment for an episodeof major depression. The morbidity and impairment associatedwith these recurrences can be devastating.’ ‹