Reply to Sertraline Versus Venlafaxine XR in Major Depressive Disorder

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Sir: The point regarding the nature of the recruited sample in our study, "A Randomized, Double-Blind, Active-Control Study of Sertraline Versus Venlafaxine XR in Major Depressive Disorder," raised by Drs. Lusicic and Jagadheesan is well taken. The participating sites were outpatient clinics affiliated with large, tertiary-care referral centers, or large community clinics that were experienced in clinical trials. Patients were recruited from those who presented for care in the centers, by self- or word-of-mouth referrals, or in response to advertisements regarding the study.’ ‹