Second-Generation Antipsychotic-Associated Diabetes Mellitus and Diabetic Ketoacidosis: Mechanisms, Predictors, and Screening Need

Antipsychotic medications, as well as schizophrenia, have beenassociated with an increased risk for diabetes. However, therelative contributions of the underlying illness, unhealthy lifestylebehaviors, and medications used to treat schizophrenia arestill unclear. Although first- and second-generation antipsychoticshave been contrasted broadly in the literature regarding theirrisks for glucoregulatory abnormalities, there is now sufficientevidence to suggest that the risk for diabetes is not uniformwithin each antipsychotic class.