Sertraline Versus Venlafaxine XR in Major Depressive Disorder

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Sir: A recent study by Shelton et al.¹ suggests that sertraline and venlafaxine XR have a comparable efficacy in treating major depressive disorder. The following comments would enable an improved understanding of this study. Shelton et al.¹ stated that participants were outpatients but did not clarify what process was involved in such recruitment.’ ‹