SIADH With Multiple Antidepressants in a Geriatric Patient

Letter to the Editor

Sir: The syndrome of inappropriate secretion of antidiuretic
hormone (SIADH) is a known side effect of psychopharmacotherapy,
having been reported with nearly all psychotropic
drugs. The mechanism of drug-induced SIADH is thought to be
mediated serotonergically, but the mechanism is not known for
certain at this time. It is often difficult to predict which patients
will develop this complication, although certain risk factors are
known, such as age = 65 years, concomitant diuretic use, and
smoking.