SSRI-TCA Combination in the Treatment of Resistant Depression

Letter to the Editor

Sir: We read with interest the article by Levitt et al. that showed the effect of combining the selective serotonin reuptake inhibitor (SSRI) fluoxetine and a tricyclic antidepressant (TCA) in resistant depression. Seth et al. also showed that 8 cases of resistant recurrent depression were successfully treated with a combination of nortriptyline and an SSRI, although Levitt et al. did not cite their article.