Successful Use of Phenelzine in Treatment-Resistant Panic Disorder

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Sir: Paroxetine, fluoxetine, sertraline, venlafaxine, clonazepam, and alprazolam are currently the only medications approved by the U.S. Food and Drug Administration for the treatment of panic disorder. In practice, first-line treatment usually involves selective serotonin reuptake inhibitors (SSRIs). Other treatment options might include tricyclic antidepressants (most commonly clomipramine and imipramine), venlafaxine, buspirone, nefazodone, β-blockers, and monoamine oxidase inhibitors (MAOIs).’ ‹