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This comprehensive how-to manual provides clear direction for clinicians working with patients who smoke. It should be of interest to all those in clinical health care and, in particular, a valuable resource to those in the fields of addiction and mental health, in which smoking and consequent rates of tobaccorelated illness are astoundingly higher than expected. The authors are leading scientist-practitioners who have provided clear strategies for treating tobacco dependence, which incorporate the latest motivational, pharmacologic, cognitive, and behavioral strategies.