Topiramate Produced Weight Loss Following Olanzapine-Induced Weight Gain in Schizophrenia

Letter to the Editor

Sir: Anticonvulsants are increasingly used as an augmentation strategy in schizophrenia. Topiramate, with the unique side effect of reducing appetite and weight, was found effective as a mild-to-moderate mood stabilizer. Topiramate was found to produce weight loss after clozapine induced weight gain in a schizophrenic patient. We report here the effect of topiramate in a patient with schizophrenia and olanzapine-induced weight gain.