Treatment of Primary Cranial Dystonia (Meige's Syndrome) With Clozapine

Letter to the Editor

Sir: Primary dystonia is the most common form of dystonia, a difficult disorder to treat. Although the effect of clozapine on tardive dystonia, a subtype of tardive dyskinesia and a serious side effect of neuroleptic drug treatment, has been reported in several case studies, there are no reports to our knowledge of improvement of primary dystonia resulting from clozapine treatment. We report on a patient with severe and persistent primary cranial dystonia (Meige’s syndrome), which successfully responded to clozapine.