Venlafaxine-Induced Increase in Urinary Frequency in 3 Women

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Sir: Urinary incontinence and increased frequency are listed as uncommon side effects of antidepressant treatment. Only 2 reports exist in the literature on the association between venlafaxine and incontinence, comprising 2 male patients and 1 female patient. These patients were receiving a combination of venlafaxine and lithium.^1,2 The present letter reports on 3 women, all in their 30s, who experienced de novo increased urinary urge, frequency, and incontinence after commencing treatment with the antidepressant venlafaxine.