Venlafaxine XR and Chronic Pelvic Pain Syndrome

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Sir: Venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor (SNRI), has been shown to have analgesic effects in neuropathic^1-3 and postsurgical pain⁴ and in pain and uncomfortable physical symptoms associated with premenstrual dysphoric disorder.⁵ This agent has also been reported to both prevent and resolve hyperalgesia in rats with experimentally produced painful neuropathic lesions.⁶