Ziprasidone Augmentation of Clozapine in 11 Patients

Sir: Clozapine, the oldest atypical antipsychotic, remains the "gold standard" in the treatment of schizophrenia and associated psychotic disorders. However, the side effects of clozapine are well known and include significant weight gain and an anticholinergic profile. The concept of adding quetiapine to clozapine with the potential to lower the dose of clozapine and thus reduce its side effect profile has been supported clinically and in the literature.