Original Research

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Recently published articles about Original Research

JCP
Vortioxetine vs Desvenlafaxine in Patients With MDD
Original Research

May 22, 2023

Compared with desvenlafaxine, vortioxetine was associated with higher rates of symptomatic and functional remission, better daily and social functioning, and greater treatment satisfaction in patients with major depression and...
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PCC
Screening and Referral Algorithm for Substance Use
Original Research

May 18, 2023

The New Hampshire Hospital Screening and Referral Algorithm, a new data driven substance use screening instrument, holds promise in improving identification of substance use in a seriously mentally ill...
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JCP
Predicting Remission From Depression in Youth Receiving Outpatient Medication Management
Original Research

May 17, 2023

Among 430 youth beginning treatment for depression, about one-quarter achieved remission within 6 months. The odds of remitting decreased as baseline symptom severity increased.
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PCC
Insomnia and Time Monitoring Behavior
Original Research

May 16, 2023

Time monitoring behavior and the associated frustration it engenders may perpetuate a negative cycle of insomnia and sleep aid use
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JCP
Research Participant Feedback on a Suicide Safety Protocol
Original Research

May 15, 2023

In women who triggered a safety protocol as part of a perinatal suicidal ideation study, 50% reported that the protocol increased engagement with treatment, and most reported a “positive...
, , , et al
JCP
Depression Treatment Response Beyond 50% Improvement
Original Research

May 8, 2023

Although most depression treatment research focuses on symptom improvement, patients have additional treatment priorities, including functioning, coping ability, and quality of life.
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JCP
Low Ghrelin and Anxiety in ARFID
Original Research

May 3, 2023

Low ghrelin levels were associated with greater anxiety in ARFID, indicating a potential target in the treatment of this disorder.
, , , et al
JCP
Endothelial Function in Youth With Bipolar Disorder
Original Research

May 1, 2023

Bipolar disorder (BD) confers risk for accelerated atherosclerosis and early cardiovascular disease. This study found that youth with BD have anomalous reactive hyperemia index (RHI)—a measure of endothelial function—which...
, , , et al
JCP
Abbreviated Suicide Crisis Syndrome Checklist and Decision Making in the ED
Original Research

May 1, 2023

The A-SCS-C had robust clinical utility and reduced clinicians’ reliance on patient-reported suicidal ideation to assess suicide risk in the ED setting.
, , , et al
PCC
Cyberchondria, Quality of Life, and the Moderating Effect of Emotions
Original Research

April 27, 2023

Excessive exposure to copious amount of information, whether of verifiable sources or not, can instigate anxious symptoms in individuals lacking adaptive emotion regulation ability.
, , , et al
PCC
Screening for Bipolar Disorder and Evaluating the RMS
Original Research

April 25, 2023

Health care providers found the Rapid Mood Screener, a new bipolar I disorder screening tool, to be superior to the widely used Mood Disorder Questionnaire in sensitivity/specificity, brevity, practicality,...
, , , et al
JCP
Efficacy of Lumateperone in Bipolar Depression With Mixed Features
Original Research

April 24, 2023

Lumateperone significantly improved depression symptoms, disease severity, and quality of life in patients with bipolar depression with mixed features.
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Consensus Report on XT Use in Practice

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Figure: Graphic promoting Consensus Report on Xanomeline-Trospium; colorful net design shown with JCP logo in lower left.

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